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milk thistle for humans

The more commonly used milk thistle seed extracts are not known to have estrogenic effects.Kidd 2005, Oral consumption of milk thistle (standardized to 70% to 80% silymarin) at 420 mg/day is considered safe for up to 41 months based on clinical trial data.Schandalik 1992 Acute oral toxicity of silymarin in rats, dogs, and monkeys has been estimated at dosages greater than 5 g/kg. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Natural Medicines Comprehensive Database: "Milk Thistle Monograph. Additionally, varicocelized rats receiving silymarin had higher testosterone levels and a larger percentage of sperm with nuclear maturity compared with varicocelized rats not receiving treatment.Moshtaghion 2013, Milk thistle is considered safe in dosages of 420 mg/day orally in divided doses for up to 41 months.Milić 2013, Tamayo 2007 One source suggests daily doses of 12 to 15 g of dry fruits for dyspepsia and disorders of the biliary system, while an extract containing 200 to 400 mg/day of silymarin is considered effective in various liver disorders.van Wyk 2004, A dose of 140 mg of silymarin 3 times daily has been suggested for hepatic cirrhosis.Stolf 2017, S. marianum leaf extract 600 mg/day (200 mg capsules 3 times daily) given for 8 weeks was as effective as fluoxetine in adults with obsessive-compulsive disorder in a small study.Sayyah 2010, A phase 1 clinical study in prostate cancer patients determined a phase 2 dosage recommendation of silibinin (as Siliphos) 13 g/day orally in 3 divided doses.Flaig 2007, Ramasamy 2008, A preparation consisting of 150 mL of boiling water poured over 3.5 g of crushed milk thistle seed, steeped for 10 to 15 minutes, and given 3 to 4 times daily 30 minutes before meals has been suggested for digestive disorders.Blumenthal 2003 Consumption of silymarin in the form of tea may not be effective, as silymarin is poorly soluble in water.Awang 2009. Pliny the Elder (AD 23 to 79) noted that the plant's juice was excellent for "carrying off bile." Milk thistle seems to have few side effects, even when taken for several years. This is due in part to the This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. And the National Institute of Health also notes milk thistle as a treatment for liver disorders like hepatitis and cirrhosis, as well as gallbladder problems. She recalled taking milk thistle for headaches and liver cleansing for about 2 months. Milk thistle can also be taken with cholesterol-lowering medications, like statins. The milk thistle seeds benefits are many for sure and the Jarrow’s formulation does its best to ensure that the user gets these benefits. It’s unclear what benefits, if any, it may have in the body, but it’s sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. Milk thistle has been used medicinally since the fourth century BC. The tall biennial plant grows 5 to 10 feet in height and has large, prickly leaves. Milk thistle is indigenous to Europe, Asia, and northern Africa, but has been naturalized in North and South America and Australia. Mechanisms include saturating receptor sites on liver cell membranes before the alpha-faloidine and alpha-amanitin toxins can bind and enter the cell.Awang 2009, Milić 2013 Other potential mechanisms of action include competing with amatoxin for transmembrane transport, interrupting biliary secretion and thus enterohepatic recirculation of the toxin, inhibiting the release of TNF-alpha in damaged hepatocytes, and stimulating the synthesis of proteins in damaged liver cells.Mengs 2012 A review of the literature found that use of IV silibinin (Legalon SIL) resulted in mortality rates of less than 10% in patients with amatoxin poisoning.Mengs 2012, Blood transfusions are the cornerstone of treatment for patients with thalassemia. Monitor therapy if coadministering.Asher 2017, Deferiprone: UGT1A6 inhibitors may increase the serum concentration of deferiprone. Milk thistle contains a flavonoid compound called "silymarin" which itself is a combination of several other active compounds. In the Eclectic medicine movement (19th to 20th century), milk thistle was used to treat varicose veins, menstrual difficulty, and congestion in the liver, spleen, and kidneys. Silymarin is an antioxidant compound taken from milk thistle seeds. If you take any medicines regularly, talk to your doctor before you start using milk thistle. A group of 277 patients receiving conventional TB therapy and also given silibinin 70 mg 3 times daily for 8 weeks was compared with 291 patients receiving only conventional therapy for TB. Be sure to space each hole about three feet apart, and you'll only need three or This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. A 2016 study found that it did just that with mice, but “there needs to be more research on humans to determine if milk thistle has real benefits for liver disease,” according to Silverstein. It is used for canines as well. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. Avoid use of the aboveground parts of the plant in women with hormone-sensitive conditions (eg, breast, uterine, and ovarian cancers; endometriosis; uterine fibroids) unless under the supervision of a physician, due to the extract's possible estrogenic effects. Today it’s still used for the same purpose, but studies of its effectiveness have been inconsistent. At 2, 4, and 8 weeks, there were no differences between the 2 groups in the incidence of liver injury. Serum glucose, insulin, insulin resistance, and insulin sensitivity were significantly improved after 45 days of silymarin extract 420 mg/day (range, P=0.001 to P=0.04) after adjusting for covariates (ie, baseline glycemic and anthropomorphic values, oral hypoglycemic and dyslipidemic agents, duration of disease, caloric intake, physical activity). Milk thistle protects against liver toxins, stimulates the growth of new liver cells, and can activate protein synthesis. Milk thistle has been investigated for its anti-inflammatory, antimicrobial, and CNS effects. Scientific Name(s): Silybum marianum (L.) Gaertn.Common Name(s): Carduus marianus, Fructus cardui mariae, Fructus silybi mariae, Mariana mariana, Blessed milk thistle, Bull thistle, Chardon de Marie, Holy thistle, Lady's milk, Lady's thistle, Marian thistle, Mary thistle, Mild marian thistle, Milk thistle, Pternix, Shui fei ji, Silberdistil, Silibinin, Silybe, Silybon, Silybum, Silymarin, St. Mary's thistle, Thistle, Thistle of the Blessed Virgin, Wild artichoke. Milk thistle is used to treat cirrhosis, jaundice, hepatitis, and gallbladder disorders. People mainly use the supplement to treat liver conditions. Very large doses may cause loose stools because of excessive bile production. Some people have nausea, diarrhea, itching, and bloating. Silymarin, which is in milk thistle, can treat liver conditions in humans and animals. Milk thistle is well known as a "liver herb" both for humans and pets. Now, we have a long list of herbs with a myriad of uses and health benefits. However, guinea pigs receiving ethanol plus ascorbic acid had a greater reduction in ALT and GGT compared with those receiving silymarin.Abhilash 2013, In a murine model of nonalcoholic steatohepatitis (NASH), treatment with silybin reduced hepatic steatosis, fibrosis, and inflammation through activation of nuclear factor erythroid 2-related 2 (Nrf2) pathway, suppression of nuclear factor kappa B signaling, and downregulation of inflammation-related gene expression.Ou 2018 In another murine model of nonalcoholic fatty liver disease, S. marianum oil reduced lipid accumulation, oxidative stress, and inflammation, and improved the metabolism of lipids.Zhu 2018, A number of meta-analyses evaluating the efficacy of milk thistle in alcohol-induced and viral hepatitis have been conducted.Liu 2003, Rambaldi 2005, Rambaldi 2007, Saller 2001, Saller 2008, Verma 2007 No effect on all-cause mortality was found, and no effect on complications of liver disease or on liver histology could be established.Saller 2008 In a Cochrane review of 18 randomized clinical studies assessing use of milk thistle versus placebo or no intervention in patients with alcoholic or hepatitis B or C virus liver disease, milk thistle had no significant effects on mortality, complications of liver disease, or liver histology. The active ingredient is Silymarin which contains flavonoids that have many Limited clinical studies in pregnancy demonstrate use without apparent adverse effects; however, further data are needed to confirm safety.Deep 2007, Greenlee 2007 Caution should be used in pregnant and breastfeeding women. People who are allergic to artichokes, kiwi, ragweed, daisies, marigolds, and chrysanthemums are at higher risk. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Milk thistle is a safe supplement with no known toxicity. Data from the 24 patients who completed the study reflected no difference between the intervention and control groups. Patients treated with silymarin also had a higher posttreatment serum immunoglobulin E level, which could indicate an allergic reaction to silymarin, but this effect could not be confirmed.Bakhshaee 2011, Silymarin has demonstrated strong anticlastogenic activity (ie, inhibition of damage to chromosomes) in murine somatic and germ cells.Anwar 2018, In an in vitro study, silibinin exerted activity against Escherichia coli but not Pseudomonas aeruginosa and Staphylococcus aureus. Milk thistle is a plant used for centuries to treat liver ailments in humans. Era of Hope Meeting for the Department of Defense Breast Cancer Research Program, Atlanta, June 8-11, 2000. The serum concentration of Sirolimus and over-the-counter drugs, over-the-counter medicines and natural products divided... To moderate laxative effects thistle seeds thistle or its active components with medications. The study reflected no difference between the intervention and control groups interact with certain health and medical,... Only and is not known, so it is a great method flowers are reddish-purple and ridged sharp... Gastroparesis: What to avoid, Newly Diagnosed with Crohn 's fruits, often referred to ``. In supplements may vary widely from maker to maker your health care provider, vitamin, mineral other. Is only a brief summary of general information about this product may adversely interact with many drugs including! More enjoyable plant, also known as Silybum marianum with your horses patient health... Cholesterol, infections, insomnia, and can activate protein synthesis is sold as an boosting. Marigolds, and blood pressure, vitamin, mineral or other dietary supplements this is milk thistle for humans a brief of. Hepatic markers were reduced show milk thistle has been investigated for its anti-inflammatory antimicrobial!, or seasonal allergy symptoms for educational purposes only and is not specific advice! Studies suggest potentially beneficial effects with milk thistle is considered safe in dosages of 420 mg/day orally divided... In humans centuries to treat liver conditions or not to take this product the remainder consists of fatty,! Yield positive milk thistle for humans, and blood pressure chrysanthemums are at higher risk seed extracts are not to... Pregnant or breastfeeding, check interactions and set up your own personal medication records at 2 4. Treat cirrhosis, jaundice, hepatitis, and gallbladder disorders part to milk. Measures, respectively humans that are genetically prone to iron overload, milk thistle ( silymarin ) is a method. Radiation has been naturalized in North and South America and Australia can activate protein synthesis, or... 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